SOLUBLE POLYMER SYNTHESIS - AN IMPROVED TRACELESS LINKER METHODOLOGY FOR ALIPHATIC C-H BOND FORMATION

Authors
ZHAO XY JUNG KW JANDA KD
Citation
Xy. Zhao et al., SOLUBLE POLYMER SYNTHESIS - AN IMPROVED TRACELESS LINKER METHODOLOGY FOR ALIPHATIC C-H BOND FORMATION, Tetrahedron letters, 38(6), 1997, pp. 977-980
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
6
Year of publication
1997
Pages
977 - 980
Database
ISI
SICI code
0040-4039(1997)38:6<977:SPS-AI>2.0.ZU;2-H
Abstract
A traceless linker was developed on a soluble polymer support. The met hodology allows for the facile attachment of molecules possessing an a lkyl halide appendage. The coupled molecule can be further functionali zed before subsequent cleavage via a two-step oxidation-reduction sequ ence. This sequence allows for the synthesis of molecules containing n o trace of the linker and the formation of a new C-H bond. (C) 1997, E lsevier Science Ltd.