THE FIRST ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY PURE HYDROXY-4',4''',7,7''-TETRAMETHOXY-8,8''-BIFLAVONE AND HYDROXY-4',4''',7,7''-TETRAMETHOXY-8,8''-BIFLAVONE AND THE RECONFIRMATION OF THEIR ABSOLUTE-CONFIGURATION

Authors
LIN GQ ZHONG M
Citation
Gq. Lin et M. Zhong, THE FIRST ENANTIOSELECTIVE SYNTHESIS OF OPTICALLY PURE HYDROXY-4',4''',7,7''-TETRAMETHOXY-8,8''-BIFLAVONE AND HYDROXY-4',4''',7,7''-TETRAMETHOXY-8,8''-BIFLAVONE AND THE RECONFIRMATION OF THEIR ABSOLUTE-CONFIGURATION, Tetrahedron letters, 38(6), 1997, pp. 1087-1090
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
6
Year of publication
1997
Pages
1087 - 1090
Database
ISI
SICI code
0040-4039(1997)38:6<1087:TFESOO>2.0.ZU;2-V
Abstract
The first enantioselective synthesis of the optically pure (R)- and (S ) - 5,5 ''-dihydroxy-4',4 ''',7,7 ''-tetramethoxy -8,8 ''-biflavone is described. The key steps involve the intramolecular oxidative couplin g of the cyanocuprate intermediate and Friedel-Crafts rearrangement. T heir absolute configuration was reconfirmed by CD spectra. (C) 1997, E lsevier Science Ltd.