PROTECTIVE EFFECT OF CHLOROGENIC ACID ON LIPID-PEROXIDATION INDUCED IN THE LIVER OF RATS BY CARBON-TETRACHLORIDE OR CO-60-IRRADIATION

The protective effect of chlorogenic acid, which occurs in tea leaves and coffee beans, on lipid peroxidation induced in the liver of rats b y the administration of carbon tetrachloride or by Co-60-irradiation w as examined. When chlorogenic acid was administered once a day for 3 s uccessive days before the administration of carbon tetrachloride, the substance suppressed the increase in lipid peroxide level in the liver . The leakage into the bloodstream of glutamate oxaloacetate and gluta mate pyruvate transaminases from the liver was also suppressed, and th is finding was supported by morphological observations. When rats admi nistered chlorogenic acid once a day for 5 successive days were irradi ated with Co-60 once a day for the last three days, the increase in se rum and liver lipid peroxide levels was significantly suppressed as co mpared with the control.