MAMMARY-TUMOR INDUCTION BY PITUITARY GRAFTING IN MALE-MICE - AN ANIMAL-MODEL FOR MALE BREAST-CANCER

Isologous anterior pituitary grafting, 4 each, to 3-4-month-old SHN an d SLN male mice resulted in an appearance of mammary tumours from 8 mo nths of age and the incidence at 12 months reached 53.8% in each strai n. All tumours were diagnosed as type B adenocarcinomas. In associatio n with the results, normal mammary gland growth and mouse mammary tumo ur virus (MMTV)-gp52 antigen levels in the submaxillary glands were st imulated by the treatment in these strains. The effect of pituitary gr afting was much less in GR/A male mice in which no mammary tumours app eared.