Differentiated thyroid cancer most commonly presents as a thyroid nodu
le. Cervical node metastases are commonly observed. In the present rep
ort, we describe the clinical presentation, pathologic findings surgic
al approach, and follow-up of 43 patients in whom the initial presenta
tion of thyroid cancer was that of an enlarged cervical lymph node. At
surgery, 65% of the patients had additional lymph node involvement. T
he thyroid pathology was papillary carcinoma in all patients, and, in
two thirds of patients, the thyroid primary was 1 cc or smaller in siz
e. Forty patients underwent thyroidectomy and modified neck dissection
; 3 were treated by thyroidectomy alone. One patient died of disease,
7 were lost to follow-up after 4 to 27 years, 5 died of unrelated caus
es, and the remaining 30 are alive and free of disease 1.5 to 33.5 yea
rs after surgery (mean: 14.8 years).