THE INDUCTION OF TOLERANCE TO ALLOANTIGENS USING MHC CLASS-I MOLECULES

The identification of approaches that allow the adult immune system to be manipulated to facilitate the induction of tolerance to alloantige ns is important for the development of more specific immunosuppressive therapy for use in transplantation. Novel strategies using genetic ma nipulation of recipient cells for the induction of tolerance to MHC cl ass I antigens have been tested in experimental systems in the past ye ar. These, together with new insights into the mechanisms responsible for maintaining peripheral tolerance, have advanced our progress in th is challenging area of transplantation biology.