EFFECT OF STOBADIN ON PRENATAL DEVELOPMENT, BEHAVIOR OF PREGNANT RATSAND THEIR OFFSPRING

Stobadin, a new prospective cardioprotective drug, was evaluated for i ts effects on prenatal development, behaviour of pregnant rats and the ir offspring. Daily oral treatment of pregnant rats with 50 mg/kg stob adin from day 6 to 15 or 20 of gestation had no overt effects on dams, embryo-foetal development or reproductive parameters. In the habituat ion test of pregnant rats and their offspring no differences in compar ison to controls were observed in the evaluated parameters of behaviou r, except slow-down of habituation (adaptability to the surrounding of the experimental cage).