SELECTIVELY HIGH EXPRESSION OF THE TRANSCRIPTION FACTOR AP1 IN TELENCEPHALIC STRUCTURES OF EPILEPTIC E1 MICE

In ddY mouse brain, the transcription factors AP1 and CREB were rich i n the cerebral cortex, hippocampus and cerebellum but relatively poor in the striatum, hypothalamus and midbrain. In contrast, the transcrip tion factor Myc was rather poorly distributed in mouse brain under the conditions employed. Among these 3 transcription factors examined, DN A binding activities of only AP1 were invariably higher in telencephal ic structures, such as the cortex, hippocampus and striatum, of the ep ileptic El mice than in those of parent ddY mice. These results sugges t that the transcription factor AP1 may be at least in part responsibl e for molecular mechanisms underlying pathogenesis of a variety of abn ormal symptoms observed in epileptic El mice.