TAXOID SIDE-CHAIN STRUCTURE DETERMINATION BY ELECTROSPRAY-IONIZATION TANDEM MASS-SPECTROMETRY

Authors
BITSCH F SHACKLETON CHL MA WW PARK G NIEDER M
Citation
F. Bitsch et al., TAXOID SIDE-CHAIN STRUCTURE DETERMINATION BY ELECTROSPRAY-IONIZATION TANDEM MASS-SPECTROMETRY, Rapid communications in mass spectrometry, 7(10), 1993, pp. 891-894
Citations number
11
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
7
Issue
10
Year of publication
1993
Pages
891 - 894
Database
ISI
SICI code
0951-4198(1993)7:10<891:TSSDBE>2.0.ZU;2-B
Abstract
A method to elucidate the side-chain structure of novel taxoids was de veloped through use of electrospray ionization tandem mass spectrometr y. The intact side-chain fragments produced by source fragmentation in the atmosphere-to-vacuum interface were further dissociated in the co llision cell of a triple quadrupole mass spectrometer. The distinctive collisionally induced dissociation mass spectra were remarkably infor mative and gave detailed information on the side-chain functionalities . This technique proved valuable in the characterization of new taxoid s produced by yew-tree cell cultures.