DYNAMICS OF THE IMMUNE-SYSTEM RESPONSE IN CEREBROSPINAL-FLUID AND BLOOD OF SIV(MAC)-INFECTED RHESUS-MONKEYS

Authors
SOPPER S HEMM S MEIXENSBERGER J COULIBALY C STAHLHENNIG C HUNSMANN G FLECKENSTEIN B TERMEULEN V DORRIES R
Citation
S. Sopper et al., DYNAMICS OF THE IMMUNE-SYSTEM RESPONSE IN CEREBROSPINAL-FLUID AND BLOOD OF SIV(MAC)-INFECTED RHESUS-MONKEYS, Journal of medical primatology, 22(2-3), 1993, pp. 138-146
Citations number
26
Categorie Soggetti
Zoology,"Veterinary Sciences
Journal title
Journal of medical primatology → ACNP
ISSN journal
00472565
Volume
22
Issue
2-3
Year of publication
1993
Pages
138 - 146
Database
ISI
SICI code
0047-2565(1993)22:2-3<138:DOTIRI>2.0.ZU;2-G
Abstract
Paired sera and CSF samples were collected from SIVmac-infected macaqu es. Animals infected with SIVmac251 maintained low gag and high env-sp ecific antibody levels in plasma. Increasing env-specific antibody tit ers in CSF were associated in one animal with strong intrathecal synth esis. SIVmac239-infected monkeys revealed high antibody titers of gag and env-specificity, in one animal accompanied by weak intrathecal syn thesis of virus-specific antibodies. In all animals, the CD4/CD8 ratio in CSF decreased faster compared to blood.