CLINICAL AND PATHOLOGICAL FINDINGS IN INFANT RHESUS MACAQUES INFECTEDWITH SIV(SMM) BY MATERNAL TRANSMISSION

Three of 12 infant rhesus macaques became infected at 9 to 12 months o f age with SIVsmm through maternal-infant transmission. Clinical probl ems seen in one or more infants included decreased CD4 cells, hypergam maglobulinemia, diarrhea, weight loss, anemia, bacterial infections, a nd terminal respiratory and CNS problems. Gross and histologic lesions due to both primary SIV infection and opportunistic infections were o bserved. The SIV-infected infants had clinical, immunologic, and patho logic similarities to those seen in pediatric HIV infection.