A TOTAL SYNTHESIS OF (-)-SLAFRAMINE FROM (-CIS-(2R,3S)-3-HYDROXYPROLINE())

Authors
KNIGHT DW SIBLEY AW
Citation
Dw. Knight et Aw. Sibley, A TOTAL SYNTHESIS OF (-)-SLAFRAMINE FROM (-CIS-(2R,3S)-3-HYDROXYPROLINE()), Tetrahedron letters, 34(41), 1993, pp. 6607-6610
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
41
Year of publication
1993
Pages
6607 - 6610
Database
ISI
SICI code
0040-4039(1993)34:41<6607:ATSO(F>2.0.ZU;2-O
Abstract
A total synthesis of the naturally occurring indolizidine (-)-Slaframi ne 4 has been achieved, starting from the cis-3-hydroxyproline derivat ive 1, in which a key step is a Julia olefination reaction using the d ianion derived from the beta-aminosulfone 5.