NEW METHOD FOR OBTAINING PYRAZINECARBOXYLIC ACID

Authors
IOVEL IG SHIMANSKAYA MV
Citation
Ig. Iovel et Mv. Shimanskaya, NEW METHOD FOR OBTAINING PYRAZINECARBOXYLIC ACID, Journal of applied chemistry of the USSR, 65(9), 1992, pp. 1696-1699
Citations number
16
Categorie Soggetti
Chemistry Applied
Journal title
Journal of applied chemistry of the USSR → ACNP
ISSN journal
0021888X
Volume
65
Issue
9
Year of publication
1992
Part
2
Pages
1696 - 1699
Database
ISI
SICI code
0021-888X(1992)65:9<1696:NMFOPA>2.0.ZU;2-#
Abstract
The generation of a carbanion from 2-methylpyrazine by phase-transfer catalysis and its autooxidation to pyrazinecarboxylic acid have been s tudied. This acid is the starting material for the effective antituber cular agent pyrazinamide. Optimum conditions were found for the synthe sis of pyrazinecarboxylic acid. Molecular oxygen, the cheapest and mos t ecological agent, was used as oxidizing agent.