CHEMOENZYMATIC SYNTHESIS OF GAL-ALPHA-1-3GAL, GAL-ALPHA-1-3GAL-BETA-1-4GLCNAC, AND THEIR PEG-CONJUGATES

Authors
MATSUO I FUJIMOTO H ISOMURA M AJISAKA K
Citation
I. Matsuo et al., CHEMOENZYMATIC SYNTHESIS OF GAL-ALPHA-1-3GAL, GAL-ALPHA-1-3GAL-BETA-1-4GLCNAC, AND THEIR PEG-CONJUGATES, Bioorganic & medicinal chemistry letters, 7(3), 1997, pp. 255-258
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
3
Year of publication
1997
Pages
255 - 258
Database
ISI
SICI code
0960-894X(1997)7:3<255:CSOGG>2.0.ZU;2-4
Abstract
Gal alpha 1-3Gal-pNP was prepared enzymatically from Gal-pNP using alp ha-galactosidase from coffee beans. PEG was attached after the reducti on of nitro group into amino group to give Gal alpha 1-3Gal-PEG conjug ate. After removing the pNP group in Gal alpha 1-3Gal-pNP, the obtaine d disaccharide was used for the synthesis of Gal alpha 1-3Gal beta 1-4 GlcNAc and corresponding trisaccharide-PEG conjugate. (C) 1997, Elsevi er Science Ltd.