STUDIES ON THE ACTIVE CONFORMATION OF NK1 ANTAGONIST CGP-49823 .1. SYNTHESIS OF CONFORMATIONALLY RESTRICTED ANALOGS

Authors
VEENSTRA SJ HAUSER K BETSCHART C
Citation
Sj. Veenstra et al., STUDIES ON THE ACTIVE CONFORMATION OF NK1 ANTAGONIST CGP-49823 .1. SYNTHESIS OF CONFORMATIONALLY RESTRICTED ANALOGS, Bioorganic & medicinal chemistry letters, 7(3), 1997, pp. 347-350
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
3
Year of publication
1997
Pages
347 - 350
Database
ISI
SICI code
0960-894X(1997)7:3<347:SOTACO>2.0.ZU;2-P
Abstract
Five conformationally restricted analogs of CGP 49823 have been synthe sized, Comparison of their in vitro, activities indicates an active co nformation of CGP 49823 in which the two aromatic rings of the benzyl and the benzoyl groups are in proximity of each other. (C) 1997, Elsev ier Science Ltd.