STUDIES ON THE ACTIVE CONFORMATION OF THE NK1 ANTAGONIST GCP-49823 .2. FLUORO-OLEFIN ANALOGS OF TERTIARY AMIDE ROTAMERS

Authors
VEENSTRA SJ HAUSER K FELBER P
Citation
Sj. Veenstra et al., STUDIES ON THE ACTIVE CONFORMATION OF THE NK1 ANTAGONIST GCP-49823 .2. FLUORO-OLEFIN ANALOGS OF TERTIARY AMIDE ROTAMERS, Bioorganic & medicinal chemistry letters, 7(3), 1997, pp. 351-354
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
3
Year of publication
1997
Pages
351 - 354
Database
ISI
SICI code
0960-894X(1997)7:3<351:SOTACO>2.0.ZU;2-S
Abstract
Four fluoro-olefin analogs of CGP 49823 have been synthesized. Compari son of their binding affinities for the NK1 receptor suggests an activ e conformation of CGP 49823, where the aromatic ring of the benzamide has a syn orientation towards the 2-benzyl substituent. (C) 1997, Else vier Science Ltd.