S. Cros et al., MODELING OF ARABINOFURANOSE AND ARABINAN .1. CONFORMATIONAL FLEXIBILITY OF THE ARABINOFURANOSE RING, Carbohydrate research, 248, 1993, pp. 81-93
The conformational behaviour of methyl beta-D- and methyl alpha-L-arab
inofuranosides have been assessed through computations performed with
the molecular mechanics program MM3 using the flexible residue method.
Energies for various envelope and twist conformers were calculated as
a function of the puckering parameters Q and phi. The gauche-gauche,
gauche-trans, and trans-gauche orientations of the primary hydroxyl gr
oups at C-5 were accounted for. Our calculations provide some insight
into extensive conformational flexibility that both molecules display
and shed light on the possible pathways for conformational interconver
sions. Both molecules display very characteristic conformational behav
iour. The conformations of methyl beta-D-arabinofuranoside, which have
been determined by single-crystal X-ray diffraction studies, are dist
ributed in two fairly deep low-energy wells. These conformations are n
o more than 1.5 kcal/mol above the respective energy minima. In the ca
se of methyl alpha-L-arabinofuranoside, crystallographic data are lack
ing and only H-1-H-1 coupling constants are available. Using suitable
equations for the H-C-C-H segments, the theoretical 3J(H-H) coupling c
onstants were calculated as a function of the two puckering parameters
, taking into account all the accessible conformations. Agreement with
the experimentally reported data confirms the high flexibility of fur
anose rings in solution.