A variable is measured at two locations separated by a given distance.
Are the values more similar to each other if the locations are orient
ed in one direction than another? This question has application to stu
dies of human genetics, epidemics, and acid rain. One obvious analytic
approach, regression on latitude and longitude, fails when data are n
on-directional (isotropic) but spatially autocorrelated. Moreover, alt
hough non-zero slope implies similarity between neighbours, the conver
se is not true. IDIFF, a statistic derived from Moran's coefficient of
spatial autocorrelation, is developed to detect general directional e
ffects that apply to the collection of data points. Simulations sugges
t that, when data have isotropic spatial autocorrelation but are incor
rectly assumed to be independent, IDIFF will at worst reject too littl
e. IDIFF has good power to distinguish epidemics that spread non-direc
tionally from those that spread in a favoured direction.