PROPERTIES AND REACTIONS OF SUBSTITUTED 1,2-THIAZETIDINE 1,1-DIOXIDES- C-3 SUBSTITUTED BETA-SULTAMS

Authors
SCHWENKKRAUS P OTTO HH
Citation
P. Schwenkkraus et Hh. Otto, PROPERTIES AND REACTIONS OF SUBSTITUTED 1,2-THIAZETIDINE 1,1-DIOXIDES- C-3 SUBSTITUTED BETA-SULTAMS, Archiv der pharmazie, 326(9), 1993, pp. 519-523
Citations number
11
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
326
Issue
9
Year of publication
1993
Pages
519 - 523
Database
ISI
SICI code
0365-6233(1993)326:9<519:PAROS1>2.0.ZU;2-8
Abstract
(RS)-3-(2-Chloroethyl)-beta-sultam (6) is obtained from methyl 4-bromo crotonate (1) by a five step synthesis. The analogous (R)-3-chlorometh yl-beta-sultam (12) is available from (R)-benzylcysteinol (9). While t he chlorine in 6 is replaced easily by iodine yielding 7, the analogou s reaction with 12 fails. The 3-(hydroxyethyl/methyl) substituted beta -sultams 17 and 21 are prepared by similar routes. All structures are established by spectroscopic