ASYMMETRIC-SYNTHESIS OF THE ANTICOCCIDIAL ANTIBIOTIC DIOLMYCIN-A1 - DETERMINATION OF ABSOLUTE STEREOCHEMISTRY

Authors
SUNAZUKA T TABATA N NAGAMITSU T TOMODA H OMURA S SMITH AB
Citation
T. Sunazuka et al., ASYMMETRIC-SYNTHESIS OF THE ANTICOCCIDIAL ANTIBIOTIC DIOLMYCIN-A1 - DETERMINATION OF ABSOLUTE STEREOCHEMISTRY, Tetrahedron letters, 34(42), 1993, pp. 6659-6660
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
42
Year of publication
1993
Pages
6659 - 6660
Database
ISI
SICI code
0040-4039(1993)34:42<6659:AOTAAD>2.0.ZU;2-I
Abstract
An asymmetric total synthesis of diolmycin A1 (1), a recently discover ed anticoccidial antibiotic, has been achieved in six steps from 2-(4- hydroxyphenyl)ethanol. The natural product comprises an unusual ca. 4: 1 mixture of enantiomers; the synthesis defined the (11R,12S) absolute configuration of the predominant (-) antipode.