A TOTAL SYNTHESIS OF 2'-DEOXY-9-DEAZAGUANOSINE (9-DEAZA-DG) AND ITS INCORPORATION INTO TRIPLE-HELIX FORMING OLIGODEOXYRIBONUCLEOTIDES WITH ANTIPARALLEL MOTIF

Authors
RAO TS LEWIS AF DURLAND RH REVANKAR GR
Citation
Ts. Rao et al., A TOTAL SYNTHESIS OF 2'-DEOXY-9-DEAZAGUANOSINE (9-DEAZA-DG) AND ITS INCORPORATION INTO TRIPLE-HELIX FORMING OLIGODEOXYRIBONUCLEOTIDES WITH ANTIPARALLEL MOTIF, Tetrahedron letters, 34(42), 1993, pp. 6709-6712
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
42
Year of publication
1993
Pages
6709 - 6712
Database
ISI
SICI code
0040-4039(1993)34:42<6709:ATSO2(>2.0.ZU;2-Q
Abstract
A simple synthesis of o-pentofuranosyl)pyrrolo[3,2-d]pyrimidin-4(3H)-o ne (9-deaza-dG) has been achieved and it has been incorporated into tr iplex forming oligonucleotides using the solid-support, phosphoramidit e chemistry. 9-Deaza-dG is effective in preventing the formation of G- tetrads in G-rich oligonucleotides.