SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING N2-(5-CARBOXYPENTYL)-2'-DEOXYGUANOSINE AND IPYRID-4-YL-CARBOXAMIDO)ETHYLTHIO]-2'-DEOXYURIDINE

Authors
WANG GY BERGSTROM DE
Citation
Gy. Wang et De. Bergstrom, SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING N2-(5-CARBOXYPENTYL)-2'-DEOXYGUANOSINE AND IPYRID-4-YL-CARBOXAMIDO)ETHYLTHIO]-2'-DEOXYURIDINE, Tetrahedron letters, 34(42), 1993, pp. 6721-6724
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
42
Year of publication
1993
Pages
6721 - 6724
Database
ISI
SICI code
0040-4039(1993)34:42<6721:SOOCN>2.0.ZU;2-N
Abstract
Synthesis of 2'-deoxyguanosine tethered at N-2 to a carboxypentyl grou p and 2'-deoxyuridine tethered through C-5 to a bipyridine is describe d. The modified nucleosides were converted to the corresponding phosph oramidites and incorporated into mono- and di-modified oligonucleotide s. The carboxypentyl group was introduced in the ester form into oligo nucleotides and recovered by hydrolysis with aqueous triethylamine.