SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING 2-(IMIDAZOL-4-YLACETAMIDO)ETHYL]-2'-DEOXYGUANOSINE

Authors
WANG GY BERGSTROM DE
Citation
Gy. Wang et De. Bergstrom, SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING 2-(IMIDAZOL-4-YLACETAMIDO)ETHYL]-2'-DEOXYGUANOSINE, Tetrahedron letters, 34(42), 1993, pp. 6725-6728
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
42
Year of publication
1993
Pages
6725 - 6728
Database
ISI
SICI code
0040-4039(1993)34:42<6725:SOOC2>2.0.ZU;2-0
Abstract
Synthesis of 2'-deoxyguanosine tethered through N-2 to an imidazole is described. The modified 2'-deoxyguanosine was converted to two differ ent phosphoramidites, one with and the other without a 6-O-protecting group. The phosphoramidites were incorporated into oligonucleotide alo ne or together with a 2'-deoxyuridine tethered to a bipyridine. Protec tion and deprotection of the imidazole are also briefly described.