EXPEDITIOUS ENANTIOSELECTIVE SYNTHESIS OF CARBOCYCLIC NUCLEOSIDES WITH ANTILEISHMANIAL ACTIVITY

Authors
DASILVA AD COIMBRA ES FOURREY JL MACHADO AS ROBERTGERO M
Citation
Ad. Dasilva et al., EXPEDITIOUS ENANTIOSELECTIVE SYNTHESIS OF CARBOCYCLIC NUCLEOSIDES WITH ANTILEISHMANIAL ACTIVITY, Tetrahedron letters, 34(42), 1993, pp. 6745-6748
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
42
Year of publication
1993
Pages
6745 - 6748
Database
ISI
SICI code
0040-4039(1993)34:42<6745:EESOCN>2.0.ZU;2-E
Abstract
A short synthesis of the neplanocin A analogue 1, lacking the hydroxym ethylene at C-4 of the parent naturally occurring carbocyclic nucleosi de, is described. Moreover, the non toxic noraristeromycin 3, an inter mediate in the synthetic scheme, was shown to exhibit a promising anti -leishmanial activity.