A MILD PROCEDURE FOR THE ANOMERIZATION OF 2'-DEOXYNUCLEOSIDES

Authors
WARD DI JEFFS SM COE PL WALKER RT
Citation
Di. Ward et al., A MILD PROCEDURE FOR THE ANOMERIZATION OF 2'-DEOXYNUCLEOSIDES, Tetrahedron letters, 34(42), 1993, pp. 6779-6782
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
42
Year of publication
1993
Pages
6779 - 6782
Database
ISI
SICI code
0040-4039(1993)34:42<6779:AMPFTA>2.0.ZU;2-X
Abstract
Addition of a catalyst containing sulfuric acid and acetic anhydride t o a solution of 3',5'-di-O-acetylthymidine in acetonitrile at room tem perature, results in the almost instantaneous production of an equilib rium mixture of alpha- and beta-anomers. Under certain conditions with increasing time, substantial quantities of a diasterioisomeric mixtur e of fully acetylated open-chain nucleosides are formed.