STIMULATION OF ALVEOLAR MACROPHAGES BY BCG VACCINE ENHANCES THE PROCESS OF LUNG FIBROSIS INDUCED BY BLEOMYCIN

Authors
CHYCZEWSKA E CHYCZEWSKI L BANKOWSKI E SULKOWSKI S NIKLINSKI J
Citation
E. Chyczewska et al., STIMULATION OF ALVEOLAR MACROPHAGES BY BCG VACCINE ENHANCES THE PROCESS OF LUNG FIBROSIS INDUCED BY BLEOMYCIN, Folia histochemica et cytobiologica, 31(3), 1993, pp. 113-116
Citations number
15
Categorie Soggetti
Cytology & Histology
Journal title
Folia histochemica et cytobiologica → ACNP
ISSN journal
02398508
Volume
31
Issue
3
Year of publication
1993
Pages
113 - 116
Database
ISI
SICI code
0239-8508(1993)31:3<113:SOAMBB>2.0.ZU;2-9
Abstract
It was found that the BCG vaccine injected subcutaneously to the rats enhances the process of lung fibrosis induced by bleomycin. Pretreatme nt of rats with this vaccine results in accumulation of activated macr ophages in lung interstitium and in the bronchoalveolar spaces. It may be suggested that the activated macrophages release various cytokines which may stimulate the proliferation of fibroblasts and biosynthesis of extracellular matrix components.