EOSINOPHILIC SCLEROSING CHOLANGITIS ASSOCIATED WITH HYPEREOSINOPHILICSYNDROME

We describe the case of a 41-yr-old man who presented with signs and s ymptoms of cholestasis including abdominal pain, jaundice, and fever, with peripheral eosinophilia of 10% and bone marrow eosinophilia. Live r biopsy revealed an eosinophilic infiltrate and an ERCP demonstrated bile duct changes, compatible with primary sclerosing cholangitis (PSC ). After treatment with prednisone and ursodeoxycholic acid, the patie nt's liver profile tests returned to normal, the ERCP changes resolved , and all symptoms disappeared. A literature review has not shown any previous reports of reversible sclerosing cholangitis, secondary to eo sinophilic infiltration. The purpose of this report is to describe eos inophilic cholangitis, an entity that mimics PSC in the context of the hypereosinophilic syndrome.