H. Ikenberg et al., HUMAN PAPILLOMAVIRUS, TYPE-16, DNA IN MULTICENTRIC ANOGENITAL NEOPLASIA ASSOCIATED WITH IDIOPATHIC PANMYELOPATHY - A CASE-REPORT, Journal of reproductive medicine, 38(10), 1993, pp. 820-822
A 27-year-old woman suffering from panmyelopathy for six years present
ed with a cervical low grade squamous intraepithelial lesion (SIL), vu
lvar high grade SIL and perianal squamous cell carcinoma with an ingui
nal metastasis. Southern blot hybridization with P-32-labeled human pa
pillomavirus (HPV) DNA revealed HPV 16 DNA in varying copy numbers in
material from the four locations. HPV 16 genomes persisting after surg
ery on the perianal tumor area were no longer detectable after betatro
n radiotherapy.