REINDUCTION OF REMISSION OF CHRONIC MYELOID-LEUKEMIA BY DONOR LEUKOCYTE TRANSFUSION FOLLOWING RELAPSE AFTER BONE-MARROW TRANSPLANTATION - RECOVERY COMPLICATED BY INITIAL PANCYTOPENIA AND LATE DERMATOMYOSITIS

A significant proportion of patients relapse after allogeneic BMT for CML. These relapses have been treated by induction of a graft-versus-l eukemia effect by transfusing donor leukocytes. We have treated a 27-y ear-old woman with interferon and donor leukocyte transfusion and a co mplete haematological and cytogenetic remission was obtained coinciden t with the onset of GVHD. Her course was complicated by prolonged and profound pancytopenia which was fully reversed by the administration o f rGM-CSF. She remains in CR with mild dermatomyositis due to chronic GVHD 17 months after the procedure.