CANINE MAMMARY-TUMOR CELL-LINES ESTABLISHED IN-VITRO

Mammary tumours are the most common tumours in the female dog. The tum ours have a complex histology and exist in epithelial, mixed and mesen chymal forms. To study the biology of canine mammary tumours, five cel l lines have been established and characterized. The results indicate that canine mammary tumours might be derived from mammary stem cells a nd that the tumour growth is independent of oestrogens. The establishe d canine mammary tumour cell lines will be valuable tools in further s tudies of the histogenesis and pathogenesis of these tumours.