ADVERSE REACTIONS TO ORAL RETINOIDS - AN UPDATE

Retinoids, both naturally occurring and synthetic, are analogues of vi tamin A. They represent a major advance in the treatment of acne and p soriasis, as well as rarer conditions such as the ichthyoses. The more frequent and widespread use of these drugs requires that the dermatol ogist be aware of the wide spectrum of adverse events that may be enco untered with their use. Some are serious and irreversible, such as ter atogenicity, necessitating great care if these drugs are given to wome n of childbearing potential. Other effects may be less severe, dose de pendent and reversible. Although not devastating to the patient, appro priate advice may reduce morbidity.