TROVAFLOXACIN, A NEW FLUOROQUINOLONE WITH POTENT ACTIVITY AGAINST STREPTOCOCCUS-PNEUMONIAE

An in vitro study of the activity of 15 antibacterial agents against 2 02 recent pediatric isolates of Streptococcus pneumoniae from urban an d rural Nebraska and rural Kentucky identified trovafloxacin ofloxacin , clindamycin, and vancomycin as the most active agents and equally ac tive against both penicillin-susceptible and -resistant strains. In co ntrast, six beta-lactams, three macrolides, and trimethoprim-sulfameth oxazole were less active overall, especially against penicillin-interm ediate and -resistant strains. Trovafloxacin inhibited all strains at a concentration of less than or equal to 0.25 mu g/ml and was 8- to 16 -fold more potent than ofloxacin or ciprofloxacin.