COMPARATIVE IN-VITRO ACTIVITIES OF TROVAFLOXACIN (CP-99,219) AND OTHER ANTIMICROBIALS AGAINST CLINICALLY SIGNIFICANT ANAEROBES

A total of 590 strains of clinically important anaerobes were tested t o determine their susceptibility to trovafloxacin. Overall, trovafloxa cin had a mode MIC of 0.25 mu g/ml and a MIC at which 90% of the isola tes were inhibited of 1 mu g/ml and had activity comparable to that of metronidazole. Trovafloxacin was 8-, 8-, 16-, 32-, and 64-fold more a ctive than ampicillin-sulbactam, clindamycin, ciprofloxacin, cefoxitin , and cefotetan, respectively. Of the Bacteroides fragilis group, 97% of the isolates were inhibited by trovafloxacin at 2 mu g/ml, and trov afloxacin was more active than ciprofloxacin, cefoxitin, cefotetan, am picillin-sulbactam, and clindamycin against Clostridium, Fusobacteirum , Porphyromonas, and Prevotella strains.