INFUSIONAL CHEMOTHERAPY COMBINED WITH RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR - ADVANTAGES AND LIMITATIONS

We have studied the simultaneous administration of granulocyte colony stimulating factor (G-CSF), given concomitantly with an infusion of ei ther doxorubicin or ifosphamide-the former, both intraarterially (i.a. ) and intravenously (i.v.), the latter, intravenously-to a group of pa tients with various malignancies. Such simultaneous administration ena bled us to substantially increase the dosage intensity of both, thereb y increasing the effectiveness of each drug. No untoward effects have been noted to date.