The DSM-III-R diagnostic criteria for alcohol dependence differ consid
erably from older criteria. We examined the association of depressive
mood and symptoms with alcohol dependence as defined by DSM-III-R in a
national sample of 2627 current drinkers. Depressive mood and symptom
s were measured with the Center for Epidemiologic Studies Depression s
cale (CESD). A significant univariate association between CESD scores
and DSM-III-R alcohol dependence was confirmed in a multivariate analy
sis that controlled for demographic characteristics, regular use of dr
ugs, alcohol consumption and recent serious interpersonal loss. Issues
in the study of depression and alcohol dependence are considered, and
potential future research directions suggested.