DIASTEREOSELECTIVE SYNTHESIS OF MEDIUM-SIZED LACTONES BY CU(BPY)CL CATALYZED CYCLIZATION OF TRICHLOROACETATES

Authors
PIRRUNG FOH HIEMSTRA H KAPTEIN B SOBRINO MEM PETRA DGI SCHOEMAKER HE SPECKAMP WN
Citation
Foh. Pirrung et al., DIASTEREOSELECTIVE SYNTHESIS OF MEDIUM-SIZED LACTONES BY CU(BPY)CL CATALYZED CYCLIZATION OF TRICHLOROACETATES, Synlett, (10), 1993, pp. 739-740
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
10
Year of publication
1993
Pages
739 - 740
Database
ISI
SICI code
0936-5214(1993):10<739:DSOMLB>2.0.ZU;2-2
Abstract
Six alkenyl trichloroacetates were heated in 1,2-dichloroethane as sol vent in the presence of 30% of the Cu(I)Cl/2,2'-bipyridine complex as catalyst at temperatures between reflux and 190-degrees-C (sealed tube ) to effect cyclization via a chlorine transfer process providing 8- a nd 9-membered lactones in moderate to good yields.