GENETIC-POLYMORPHISM OF OROSOMUCOID (ORM) IN POPULATIONS OF THE UNITED-KINGDOM, INDIAN SUBCONTINENT, AND CAMBODIA

Authors
MASTANA SS JAYASEKARA R FISHER P SOKOL RJ PAPIHA SS
Citation
Ss. Mastana et al., GENETIC-POLYMORPHISM OF OROSOMUCOID (ORM) IN POPULATIONS OF THE UNITED-KINGDOM, INDIAN SUBCONTINENT, AND CAMBODIA, JPN J HUM G, 38(3), 1993, pp. 289-296
Citations number
29
Categorie Soggetti
Genetics & Heredity
Journal title
Japanese journal of human genetics → ACNP
ISSN journal
09168478
Volume
38
Issue
3
Year of publication
1993
Pages
289 - 296
Database
ISI
SICI code
0916-8478(1993)38:3<289:GOO(IP>2.0.ZU;2-T
Abstract
The genetic variation of the human serum orosomucoid (ORM) was investi gated by isoelectric focusing (IEF) followed by immunofixation in 15 d ifferent populations from East Midlands (United Kingdom), India, Sri L anka, and Cambodia. Statistically significant differences were observe d between various Asiatic and British populations, however differences within Asiatic and European populations were minor. The distribution of ORM1 alleles in populations investigated to date suggests an intere sting east-west geographical cline. There is a suggestion that present day wide polymorphism at the ORM1 locus may be influenced by selectio n.