DETECTION OF THE PML RAR-ALPHA FUSION GENE IN ACUTE PROMYELOCYTIC LEUKEMIA WITH A COMPLEX TRANSLOCATION INVOLVING CHROMOSOME-15, CHROMOSOME-17, AND CHROMOSOME-18/

Authors
OGAWA S MITANI K SATO Y SUGIMOTO K TOYOSHIMA H MANO H TAKAKU F YAZAKI Y HIRAI H
Citation
S. Ogawa et al., DETECTION OF THE PML RAR-ALPHA FUSION GENE IN ACUTE PROMYELOCYTIC LEUKEMIA WITH A COMPLEX TRANSLOCATION INVOLVING CHROMOSOME-15, CHROMOSOME-17, AND CHROMOSOME-18/, Cancer genetics and cytogenetics, 69(2), 1993, pp. 113-117
Citations number
23
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
69
Issue
2
Year of publication
1993
Pages
113 - 117
Database
ISI
SICI code
0165-4608(1993)69:2<113:DOTPRF>2.0.ZU;2-5
Abstract
We report a case with typical clinical features of acute promyelocytic leukemia (APL) carrying an atypical chromosomal aberration involving chromosomes 15, 17, and 18. Molecular analysis using Southern blot hyb ridization and reverse transcriptase-polymerase chain reaction (RT-PCR ) proved the creation of the PML/RARalpha fusion gene in this case. Th ese findings support the notion that this fusion is of crucial importa nce to leukemogenesis of APL.