CHROMOSOME-12 ALTERATIONS AND C-KI-RAS MUTATIONS IN COLORECTAL TUMORS

Authors
MULERIS M LAURENTPUIG P SALMON RJ THOMAS G DUTRILLAUX B
Citation
M. Muleris et al., CHROMOSOME-12 ALTERATIONS AND C-KI-RAS MUTATIONS IN COLORECTAL TUMORS, Cancer genetics and cytogenetics, 69(2), 1993, pp. 161-162
Citations number
15
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
69
Issue
2
Year of publication
1993
Pages
161 - 162
Database
ISI
SICI code
0165-4608(1993)69:2<161:CAACMI>2.0.ZU;2-F
Abstract
c-Ki-ras mutations and gains of chromosome 12, where this gene is mapp ed, were both studied in a series of 47 colorectal cancers. Mutations at codon 12 and 13 were detected in 17 (36%) and gains of chromosome 1 2 in 7 (15%) cases. In this sample, gains of chromosome 12 occur in tu mors either with or without c-Ki-ras mutations, suggesting that gains of chromosome 12 are independent from the mutation of c-Ki-ras.