STRUCTURAL MODIFICATION OF 5-ARYL-2,3-DIHYDROIMIDAZO[2,1-A]ISOQUINOLINE PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONISTS

Authors
HOULIHAN WJ CHEON SH PARRINO VA HANDLEY DA LARSON DA
Citation
Wj. Houlihan et al., STRUCTURAL MODIFICATION OF 5-ARYL-2,3-DIHYDROIMIDAZO[2,1-A]ISOQUINOLINE PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONISTS, Journal of medicinal chemistry, 36(21), 1993, pp. 3098-3102
Citations number
10
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
36
Issue
21
Year of publication
1993
Pages
3098 - 3102
Database
ISI
SICI code
0022-2623(1993)36:21<3098:SMO5>2.0.ZU;2-D
Abstract
In an effort to determine the effect of modification of the imidazo[2, 1-a]isoquinoline portion of the PAF-receptor antagonist SDZ 64-412 (1) , several new analogs were prepared and evaluated in vitro and in vivo . One of these, yl]-2,3-dihydroimidazo[1,2-a]thieno[2,3-c]pyridine (6) was 4-5 times more potent than 1 in inhibiting PAF-induced bronchocon striction and hemoconcentration when administered po to the guinea pig .