R. Sarin et al., THERAPEUTIC FACTORS INFLUENCING THE COSMETIC OUTCOME AND LATE COMPLICATIONS IN THE CONSERVATIVE MANAGEMENT OF EARLY BREAST-CANCER, International journal of radiation oncology, biology, physics, 27(2), 1993, pp. 285-292
Citations number
32
Categorie Soggetti
Oncology,"Radiology,Nuclear Medicine & Medical Imaging
Purpose: To investigate the impact of clinical and physical parameters
on the cosmetic result and complications, in cancer breast treated wi
th conservative surgery and definitive irradiation. Methods and Materi
als: Between October 1980 and December 1990, 289 patients were treated
with lumpectomy and/or axillary dissection, radical irradiation with
or without adjuvant therapy. The radiation therapy technique consisted
of external beam therapy followed by an Ir-192 implant or electron be
am boost. Univariate and multivariate analysis were used to evaluate t
he correlation between multiple factors affecting the cosmetic outcome
and the complications. Results: Of 289 patients, cosmesis was evaluab
le in 285 and recorded as excellent to good in 226 (79%), fair in 35 (
12%), and poor in 24 (9%). On multivariate analysis of these results,
a high dose per fraction (p = .0018), and use of electrons as boost to
the tumor bed (p = .001) were found to be significant. When patients
boosted with electrons were excluded, a high boost dose (p = .0433) wa
s also found significant. Fifteen (5%) patients developed severe late
radiation sequelae and 14 (5%) moderate or severe arm edema. On multiv
ariate analysis only dose per fraction of 2.5 Gy (p < .0001) and highe
r boost doses (p = .017) were significant. Conclusion: In 289 patients
of early breast cancer treated with conservative surgery and radical
irradiation, multivariate analysis suggests that higher dose per fract
ion with teletherapy and higher brachytherapy boost dose adversely aff
ect cosmesis and contribute to the late complications.