TETRACYCLINE PLEURODESIS - ASSOCIATED ACUTE-RENAL-FAILURE

Chemical pleurodesis is a frequently performed procedure for pneumotho rax and effusion and significant adverse effects are unusual. We prese nt a previously unreported case of acute renal failure associated with tetracycline pleurodesis. Recent studies have shown that intrapleural drug administration may lead to therapeutic serum levels. Systemic to xic drug effects may therefore be noted with chemical pleurodesants su ch as tetracycline. Alternative methods of pleurodesis should always b e considered if a sensitivity or metabolic abnormality is suspected.