PROGNOSTIC FACTORS OF HEPATOCELLULAR-CARC INOMA - A MULTIVARIATE-ANALYSIS IN 84 CASES

To identify prognostic factors taking in account recent advances in di agnosis and treatment, 24 clinical, biological and morphological facto rs were evaluated by means of uni- and multivariate analysis in 84 pat ients with hepatocellular carcinoma diagnosed between 1984 and 1991. O kuda's grading (P < 0.01), creatininemia (P < 0.01), and treatment (P < 0.05) were independant prognostic factors. Des-gamma-carboxyprothrom bin reached a significant level (P < 0. 05) in a subgroup of 32 recent patients but its prognostic value needs to be confirmed. Further pros pective randomized trials comparing surgical and non-surgical treatmen t should take these factors into account.