Jw. Tapsall et al., THE INCIDENCE OF GONORRHEA AND THE ANTIBIOTIC-SENSITIVITY OF GONOCOCCI IN AUSTRALIA, 1981-1991, Genitourinary medicine, 69(5), 1993, pp. 364-369
Objective-To review and analyse the changing incidence of gonorrhoea a
nd the increasing antibiotic resistance in gonococci in Australia from
1981 to 1991. Design-Use of data from the sample of gonorrhoea in Aus
tralia examined by the Australian Gonococcal Surveillance Programme (A
GSP), a continuing long-term multi-centric study of gonococcal disease
and gonococcal susceptibility to antibiotics, over the period 1 July,
1981 to 30 June, 1991. Results-Over 32,000 cases and strains from def
ined sources were examined in the 10 year study period. The number of
cases of gonorrhoea in the sample decline from a peak of 6599 in 1982-
1983 to 1121 in the final year under review, a reduction of 83%. Perio
ds when greater than average reductions in incidence occurred in diffe
rent groups were noted. Ano-rectal gonorrhoea in men decreased sharply
in 1985 during an overall decline of 92.5% recorded between 1 july, 1
981 to 30 June, 1987. However, the incidence of ano-rectal cases in ma
les rose in subsequent years while gonorrhoea, overall, continued to d
ecrease and at a greater rate after 1985. Antibiotic resistance in gon
ococci in Australia was manifested both as a progressive increase in t
he levels of instrinsic resistance to the penicillins and through the
appearance and spread of penicillinase-producing N gonorrhoeae (PPNG).
At the end of the review period in June, 1991, 8.8% of gonococcal iso
lates in Australia showed high levels of intrinsic resistance to the p
enicillins and 13% of strains were PPNG. These separate mechanisms of
resistance appeared at different times in different parts of Australia
, and their importance also varied throughout the country. Most infect
ions with PPNG were acquired by men overseas whereas most women with P
PNG were infected locally. Endemic spread of PPNG was a significant pr
oblem in Sydney and Melbourne, but decreased in importance in the late
r years of the study. Conclusions-In the past decade a large reduction
in the incidence of gonorrhoea and, by implication, other STDs has oc
curred in the past decade in Australia. In some groups of patients the
decline in incidence is continuing while in others a slight increase
has been noted. Resistance to antibiotics of gonococci in Australia wa
s mainly restricted to the penicillins, but through both chromosomal a
nd plasmid-mediated mechanisms. This resistance was seen particularly
in Sydney and Melbourne where endemic cycles of transmission of PPNG w
ere established, and in infected travellers from S-E Asia in other cen
tres. Valid and comparable, and regionally relevant data are a continu
ing requirement for assessing and modifying antibiotic treatment regim
ens for gonococcal disease.