EFFECT OF CILOSTAZOL ON TRIGLYCERIDE-METABOLISM IN RATS

The effect of cilostazol, a potent inhibitor of platelet aggregation, on triglyceride metabolism was studied using 20 normal Wistar rats. Ci lostazol (100 mg/kg) was administered to rats twice daily for 2 weeks. Triglyceride turnover was estimated using Triton WR1339 after an over night fast. There were no significant differences in plasma insulin, g lucose, cholesterol, and phospholipid levels between cilostazol-admini stered and control rats. The plasma triglyceride level in cilostazol-t reated rats tended to decrease and the triglyceride secretion rate was significantly suppressed. The plasma free fatty acid level was not af fected by this drug. The lipid composition of newly secreted very-low- density lipoprotein (VLDL) in cilostazol-administered rats did not dif fer from that in control rats. Thus it was suggested from the present data that cilostazol can suppress VLDL-triglyceride production from a nonfatty acid source in normal rats.