INHIBITORY EFFECT OF SELENIUM AND CHANGE OF GLUTATHIONE-PEROXIDASE ACTIVITY ON RAT GLIOMA

Authors
ZHANG ZH KIMURA M ITOKAWA Y
Citation
Zh. Zhang et al., INHIBITORY EFFECT OF SELENIUM AND CHANGE OF GLUTATHIONE-PEROXIDASE ACTIVITY ON RAT GLIOMA, Biological trace element research, 55(1-2), 1996, pp. 31-38
Citations number
31
Categorie Soggetti
Biology
Journal title
Biological trace element research → ACNP
ISSN journal
01634984
Volume
55
Issue
1-2
Year of publication
1996
Pages
31 - 38
Database
ISI
SICI code
0163-4984(1996)55:1-2<31:IEOSAC>2.0.ZU;2-Q
Abstract
The inhibitory effect of selenium (Se) and change of glutathione perox idase activity during the development of brain tumors was investigated in Wistar rats. Four rat groups classified to match by age and weight were fed a diet containing 0, 0.5, 2.0, and 4.0 mu g Se/g. After 6 wk , the rats were injected with 3 x 10(6) Cg cells into the right fronta l lobe parenchyma. Survival was significantly longer in the 0.5 and 2. 0 mu g Se/g groups than in the Se-free and 4.0 mu g Se/g groups. The a ctivity of glutathione peroxidase after development of tumors was sign ificantly higher in the high Se group at 18 and 30 d.