Zh. Zhang et al., INHIBITORY EFFECT OF SELENIUM AND CHANGE OF GLUTATHIONE-PEROXIDASE ACTIVITY ON RAT GLIOMA, Biological trace element research, 55(1-2), 1996, pp. 31-38
The inhibitory effect of selenium (Se) and change of glutathione perox
idase activity during the development of brain tumors was investigated
in Wistar rats. Four rat groups classified to match by age and weight
were fed a diet containing 0, 0.5, 2.0, and 4.0 mu g Se/g. After 6 wk
, the rats were injected with 3 x 10(6) Cg cells into the right fronta
l lobe parenchyma. Survival was significantly longer in the 0.5 and 2.
0 mu g Se/g groups than in the Se-free and 4.0 mu g Se/g groups. The a
ctivity of glutathione peroxidase after development of tumors was sign
ificantly higher in the high Se group at 18 and 30 d.