A NOVEL RAPID THROUGHPUT PHOTOTOLERANCE SCREEN IN MICE

Authors
SHAPIRO MA SESNIE JC JOANNIDES ET MALTA TE DEVER JA HEIFETZ CL
Citation
Ma. Shapiro et al., A NOVEL RAPID THROUGHPUT PHOTOTOLERANCE SCREEN IN MICE, Journal of pharmacological and toxicological methods, 36(4), 1996, pp. 185-187
Citations number
11
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Journal of pharmacological and toxicological methods → ACNP
ISSN journal
10568719
Volume
36
Issue
4
Year of publication
1996
Pages
185 - 187
Database
ISI
SICI code
1056-8719(1996)36:4<185:ANRTPS>2.0.ZU;2-#
Abstract
A relatively simple, rapid throughput phototolerance screen in small a nimals would be very useful in early drug development. It could priori tize or select potential lead compounds from among a number of analogs with similar biological activities. This study describes an in vivo m ouse phototolerance screen established for that purpose. It also repor ts phototolerance data with standard reference drugs obtained using th is screen. (C) 1996 Elsevier Science Inc.