PREPARATION AND CHARACTERIZATION OF CYCLODEXTRIN COMPLEXES OF THE INSECTICIDES ALDICARB AND SULPROFOS

The beta-cyclodextrin (BCD) complexes of the insecticides sulprofos an d aldicarb have been prepared in an aqueous medium. Attempts to form a BCD complex of the insecticide thiodicarb were apparently unsuccessfu l. The BCD complexes were characterized by solubility properties, elem ental analyses, and spectral studies. Spectral studies included ultrav iolet, infrared, proton NMR, and C-13 NMR spectroscopy. The spectral d ifferences between the BCD complex and its individual components were greatest in the case of aldicarb, providing evidence confirming the fo rmation of a true inclusion complex. Since the spectral differences be tween the sulprofos-BCD complex and its components were small, it was analyzed by differential scanning calorimetry (DSC). The DSC thermogra m of the complex differed markedly from that of sulprofos or BCD, sugg esting the formation of an inclusion complex; however, an external ass ociative complex cannot be ruled out.