In a review and critical appraisal of the literature on antibiotic the
rapy for acute otitis media in children between 1939 and 1991, poor ev
idence supported the routine use of antibiotic therapy. Good evidence
supported initial symptomatic treatment and institution of antibiotic
therapy only in cases of an irregular course (fever or pain for more t
han 48 to 72 hours) in children 2 years and older. This approach canno
t be recommended for children 2 years and younger because this age gro
up has been excluded from most studies.