THE YEAST CANDIDA-ALBICANS HAS A CLONAL MODE OF REPRODUCTION IN A POPULATION OF INFECTED HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENTS

Authors
PUJOL C REYNES J RENAUD F RAYMOND M TIBAYRENC M AYALA FJ JANBON F MALLIE M BASTIDE JM
Citation
C. Pujol et al., THE YEAST CANDIDA-ALBICANS HAS A CLONAL MODE OF REPRODUCTION IN A POPULATION OF INFECTED HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE PATIENTS, Proceedings of the National Academy of Sciences of the United Statesof America, 90(20), 1993, pp. 9456-9459
Citations number
24
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
90
Issue
20
Year of publication
1993
Pages
9456 - 9459
Database
ISI
SICI code
0027-8424(1993)90:20<9456:TYCHAC>2.0.ZU;2-5
Abstract
To ascertain the population structure of Candida albicans, we have car ried out a multilocus enzyme electrophoresis study based on the analys is of 21 gene loci. We have thus characterized 55 strains isolated one each from 55 human immunodeficiency virus-positive patients. There is considerable polymorphism among the strains. A population-genetic ana lysis indicates that the two fundamental consequences of sexual reprod uction (i.e., segregation and recombination) are apparently absent in this population of C. albicans. The population structure of C. albican s appears to be clonal, a state of affairs that has important medical and biological consequences.